Medication support

Zepbound® support: everyday help while you’re on it

What people commonly experience on Zepbound (tirzepatide), what to ask your prescriber, when to call, and how Aven helps with the days in between.

Last reviewed October 15, 2026
Label checked: revised August 2026
3 sources

Aven is not affiliated with or endorsed by Eli Lilly and Company. Zepbound® is a registered trademark of Eli Lilly and Company.

The short answer

Zepbound is an injectable prescription medicine that contains tirzepatide. It’s used with a reduced-calorie diet and increased physical activity.¹ Stomach-related side effects are the most common, especially while the dose is being increased.^1,2 Aven helps with the everyday part: side-effect days, food, habits, shot-day reminders, and staying on track. Your prescriber handles your dose.

Zepbound at a glance

Active ingredient: Tirzepatide
What it is: A GIP and GLP-1 receptor agonist, given as an injection
Approved for: Adults with obesity, or overweight with a weight-related condition, to lose excess weight and keep it off long term; and moderate to severe obstructive sleep apnea in adults with obesity¹
Used with: A reduced-calorie diet and increased physical activity¹
Your dose: Set and changed only by your prescriber. See the official prescribing information.

Zepbound shouldn’t be used with other tirzepatide products or other GLP-1 medicines.¹ Tell your prescriber about every medicine you take.

What people commonly experience

The prescribing information lists these as the most common side effects:¹

Nausea
Diarrhea
Vomiting
Constipation
Stomach pain
Indigestion
Injection site reactions
Feeling tired
Allergic reactions
Belching
Hair loss
Heartburn

In the SURMOUNT-1 trial, the most common side effects were stomach-related. Most were mild to moderate and happened mainly while the dose was being increased.² Nausea, vomiting, and diarrhea can dehydrate you, so keep sipping fluids on hard days.¹

What helps on nausea days

How Aven helps while you’re on Zepbound

Aven doesn’t replace your prescriber. It’s the support between visits:

Shot-day reminders, set just by asking. Reminders never include dose amounts.
Side-effect days: practical comfort ideas, a follow-up the next morning, and a clear line to your prescriber.
Protein and strength: keeping muscle matters as you lose weight, and protein plus regular strength training helps.³ Aven helps you build both into your week.
Goals and progress: weigh-ins by text, your weekly trend, and milestones, from your first week to long-term maintenance.
Before appointments: a summary of what you’ve shared, and the questions you want to ask.

Aven

Sunday 7:40 PM
Can you remind me every Sunday at 8 that tomorrow is shot day?
Done ✓ Every Sunday at 8 PM. Want a check-in Tuesday morning too? That’s usually when your stomach is touchy.
Yes, good idea
Tuesday 8:10 AM
Morning! How’s your stomach today? Small breakfast and sips of water. Yogurt still sitting well?

Questions to bring to your prescriber

What should I do if side effects make it hard to eat or drink?
How will we decide when, or whether, my dose changes?
I take birth control pills. Should I use another method for a while? The label says birth control pills may not work as well while using Zepbound, and your provider may recommend another method after you start or increase your dose.¹
I take insulin or a sulfonylurea. What should I know about low blood sugar?¹
I have a procedure with anesthesia coming up. What do my other providers need to know?¹

Aven can keep this list for you. Text a question when it comes up, and ask for the list before your visit.

When to call your prescriber, or 911

Call your prescriber

Nausea, vomiting, or diarrhea that won’t go away. Losing fluids can lead to kidney problems.¹
Stomach problems that are severe or won’t go away.
Signs of gallbladder problems: pain in your upper stomach, fever, yellowing of your skin or eyes, or clay-colored stools.
A lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.
Changes in your vision, if you have type 2 diabetes.
Right away: severe pain in your stomach area that won’t go away, with or without vomiting, sometimes felt through to your back.

Call 911

Signs of a serious allergic reaction: swelling of your face, lips, tongue, or throat; trouble breathing or swallowing; severe rash or itching; fainting or feeling dizzy; a very rapid heartbeat.

From the Zepbound Medication Guide.¹ It isn’t the full list; read the Medication Guide that comes with your medicine. You can also report side effects to the FDA at 1-800-FDA-1088.

What Aven does, and doesn’t do

Aven does

Remind you about shot day, refills, and appointments
Check in on side-effect days and follow up
Help with food, protein, and habits
Summarize what you’ve shared before a visit

Aven doesn’t

Give dose amounts, schedules, or changes
Diagnose anything or replace your care team
Wait in an emergency: it tells you to call 911 right away

Questions people ask

Can Aven tell me what dose of Zepbound to take?

No. Your dose and when it changes are decided by your prescriber. Aven helps with the everyday part: side-effect days, food, habits, reminders, and staying on track. Questions about your dose always go to your prescriber.

What are the most common side effects of Zepbound?

According to the prescribing information, the most common side effects include nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn.¹ In the SURMOUNT-1 trial, stomach-related side effects were mostly mild to moderate and happened mainly while the dose was being increased.²

Can Aven remind me about my Zepbound shot?

Yes. Ask in plain words, like “remind me every Sunday at 8 PM that tomorrow is shot day,” and Aven texts you at that time. Reminders never include dose amounts.

Is Aven made by Eli Lilly?

No. Aven is made by Beck Health and is not affiliated with or endorsed by Eli Lilly and Company or any drug manufacturer. Zepbound® is a registered trademark of Eli Lilly and Company.

Sources

Zepbound® (tirzepatide) Prescribing Information and Medication Guide. Eli Lilly and Company; revised August 2026. DailyMed
Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1). N Engl J Med. 2022;387(3):205-216. doi:10.1056/NEJMoa2206038
Mozaffarian D, Agarwal M, Aggarwal M, et al. Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Am J Clin Nutr. 2025;122(1):344-367. doi:10.1016/j.ajcnut.2025.04.023

This page is general education, not medical advice, and is not a substitute for the prescribing information or your prescriber. Aven is not affiliated with Eli Lilly and Company or any drug manufacturer.